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KMID : 0438219750120030821
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Korea University Medical Journal
1975 Volume.12 No. 3 p.821 ~ p.828
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The Effects of Acidic Amino Acids in the Brain Metabalism in Rat
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Abstract
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It is known that the two principal naturally occurring dicarboxylic amino acids, 1-glutamic acid and 1-aspartic acid, both have the same kind of excitatory action in the central nervous system. This experiment was carried out to investigate the metabolic function of 1-glutamic acid and 1-aspartic acid on central nervous system besides its role as a transmitter. The oxygen consumption rate of the slices of cerebral cortex, cerebellum, thalamus, medulla oblongata, ventral and dorsal spinal cord in alino rat were determined using the Warburg´s manometric apparatus supplying 100% oxygen with substrate in the Krebs-Ringer bicarbonate buffer medium (pH 7.4) with or without glucose.
The results are summarized as follows:
1. Glucose increased the oxygen consumption rate of all the region of central nervous system.
2. Glutamic acid increased the oxygen consumption rate of brain and spinal cord, especially in the ventral spinal cord.
3. Aspartic acid decreased the oxygen consumption of forebrain tissues, whereas increased of the spinal cord, especially in the ventral spinal cord.
4. In the presence of glucose, aspartic acid oxydation occured much more rapidly in the spinal cord, especially in the ventral spinal cord than in the brain.
According to results of the above findings. It may be speculated that glutamic acid may be utilized as oxydative substrate, while aspartic acid can be utilized only with the presence of glucose in the brain level.
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